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| Name | W | L | SV | ERA | G | GS | IP | HA | R | ER | HR | BB | K | WHIP | OAVG | BABIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Jamie Moyer SP | 2 | 1 | 0 | 3.08 | 22 | 4 | 52.2 | 42 | 21 | 18 | 7 | 14 | 35 | 1.06 | .213 | .224 | 0.8 |
| Ed Walsh SP | 5 | 2 | 1 | 3.12 | 14 | 12 | 86.2 | 52 | 32 | 30 | 15 | 37 | 83 | 1.03 | .175 | .186 | 1.6 |
| Akinori Otsuka RP | 2 | 1 | 1 | 3.33 | 19 | 0 | 24.1 | 19 | 10 | 9 | 3 | 11 | 24 | 1.23 | .209 | .250 | 0.4 |
| Ted Lilly SP | 0 | 0 | 0 | 4.15 | 5 | 0 | 8.2 | 10 | 4 | 4 | 2 | 5 | 5 | 1.73 | .294 | .286 | -0.1 |
| Mark Buehrle SP | 5 | 7 | 0 | 4.45 | 14 | 14 | 89.0 | 79 | 44 | 44 | 19 | 24 | 59 | 1.16 | .242 | .241 | 0.9 |
| Ben Sheets SP | 4 | 5 | 0 | 4.69 | 13 | 13 | 80.2 | 76 | 45 | 42 | 13 | 18 | 68 | 1.17 | .249 | .280 | 1.8 |
| Cristóbal Torriente CF | 0 | 0 | 0 | 4.91 | 3 | 0 | 3.2 | 3 | 2 | 2 | 1 | 1 | 3 | 1.09 | .231 | .222 | -0.0 |
| David Price RP | 3 | 3 | 1 | 5.19 | 16 | 11 | 69.1 | 81 | 45 | 40 | 17 | 19 | 67 | 1.44 | .288 | .323 | 0.8 |
| Hoyt Wilhelm RP | 3 | 3 | 2 | 5.49 | 24 | 0 | 39.1 | 35 | 24 | 24 | 12 | 17 | 33 | 1.32 | .233 | .217 | -0.6 |
| A. J. Minter RP | 2 | 3 | 10 | 5.79 | 22 | 0 | 18.2 | 19 | 12 | 12 | 3 | 10 | 7 | 1.55 | .264 | .258 | -0.2 |
| Tricky Nichols SP | 4 | 6 | 0 | 6.03 | 15 | 15 | 77.2 | 93 | 55 | 52 | 17 | 29 | 46 | 1.57 | .302 | .310 | 0.3 |
| Larry Twitchell SP | 3 | 2 | 0 | 6.06 | 18 | 1 | 35.2 | 47 | 25 | 24 | 6 | 7 | 30 | 1.51 | .322 | .369 | 0.6 |
| Billy Loes RP | 0 | 1 | 1 | 6.27 | 19 | 0 | 18.2 | 26 | 14 | 13 | 8 | 9 | 14 | 1.87 | .313 | .295 | -0.7 |
| Tom Williams RP | 1 | 0 | 0 | 7.50 | 11 | 0 | 12.0 | 12 | 10 | 10 | 2 | 4 | 14 | 1.33 | .255 | .323 | 0.2 |
| Joe Lake SP | 0 | 1 | 0 | 9.00 | 5 | 0 | 12.0 | 20 | 12 | 12 | 3 | 3 | 12 | 1.92 | .357 | .415 | 0.0 |
