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| Name | W | L | SV | ERA | G | GS | IP | HA | R | ER | HR | BB | K | WHIP | OAVG | BABIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Akinori Otsuka RP | 3 | 1 | 1 | 2.56 | 23 | 0 | 31.2 | 22 | 10 | 9 | 3 | 14 | 31 | 1.14 | .193 | .237 | 0.7 |
| Jamie Moyer SP | 2 | 1 | 0 | 3.06 | 24 | 6 | 64.2 | 54 | 25 | 22 | 9 | 19 | 40 | 1.13 | .223 | .232 | 0.9 |
| Ed Walsh SP | 6 | 3 | 1 | 3.41 | 17 | 15 | 105.2 | 71 | 42 | 40 | 21 | 41 | 100 | 1.06 | .192 | .201 | 1.7 |
| Ted Lilly SP | 0 | 0 | 0 | 4.15 | 5 | 0 | 8.2 | 10 | 4 | 4 | 2 | 5 | 5 | 1.73 | .294 | .286 | -0.1 |
| Mark Buehrle SP | 5 | 7 | 0 | 4.83 | 17 | 17 | 104.1 | 101 | 57 | 56 | 22 | 30 | 69 | 1.26 | .260 | .264 | 1.1 |
| Cristóbal Torriente CF | 0 | 0 | 0 | 4.91 | 3 | 0 | 3.2 | 3 | 2 | 2 | 1 | 1 | 3 | 1.09 | .231 | .222 | -0.0 |
| Ben Sheets SP | 4 | 8 | 0 | 5.08 | 16 | 16 | 95.2 | 94 | 57 | 54 | 18 | 28 | 85 | 1.28 | .259 | .291 | 1.7 |
| David Price RP | 3 | 4 | 1 | 5.35 | 23 | 11 | 79.0 | 88 | 52 | 47 | 19 | 23 | 73 | 1.41 | .278 | .305 | 0.8 |
| A. J. Minter RP | 3 | 3 | 12 | 5.56 | 26 | 0 | 22.2 | 23 | 14 | 14 | 5 | 10 | 11 | 1.46 | .261 | .250 | -0.3 |
| Hoyt Wilhelm RP | 3 | 3 | 2 | 5.60 | 30 | 0 | 45.0 | 40 | 28 | 28 | 13 | 21 | 38 | 1.36 | .233 | .221 | -0.6 |
| Tom Williams RP | 1 | 0 | 1 | 5.71 | 16 | 0 | 17.1 | 15 | 11 | 11 | 2 | 5 | 18 | 1.15 | .227 | .283 | 0.3 |
| Joe Lake SP | 3 | 2 | 0 | 5.88 | 12 | 0 | 26.0 | 32 | 18 | 17 | 5 | 5 | 21 | 1.42 | .294 | .325 | 0.2 |
| Larry Twitchell SP | 3 | 2 | 0 | 6.06 | 18 | 1 | 35.2 | 47 | 25 | 24 | 6 | 7 | 30 | 1.51 | .322 | .369 | 0.6 |
| Billy Loes RP | 0 | 1 | 1 | 6.27 | 19 | 0 | 18.2 | 26 | 14 | 13 | 8 | 9 | 14 | 1.87 | .313 | .295 | -0.6 |
| Tricky Nichols SP | 4 | 8 | 0 | 6.93 | 18 | 18 | 89.2 | 113 | 73 | 69 | 24 | 36 | 55 | 1.66 | .312 | .314 | -0.2 |
