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| Name | W | L | SV | ERA | G | GS | IP | HA | R | ER | HR | BB | K | WHIP | OAVG | BABIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Akinori Otsuka RP | 5 | 2 | 6 | 2.22 | 34 | 0 | 44.2 | 30 | 12 | 11 | 3 | 18 | 37 | 1.07 | .190 | .229 | 1.3 |
| Cristóbal Torriente LF | 2 | 0 | 0 | 3.92 | 8 | 3 | 20.2 | 17 | 10 | 9 | 3 | 6 | 10 | 1.11 | .230 | .230 | 0.2 |
| Ed Walsh SP | 10 | 11 | 1 | 3.94 | 34 | 32 | 205.1 | 158 | 99 | 90 | 46 | 78 | 201 | 1.15 | .213 | .225 | 3.0 |
| Ted Lilly SP | 0 | 0 | 0 | 4.15 | 5 | 0 | 8.2 | 10 | 4 | 4 | 2 | 5 | 5 | 1.73 | .294 | .286 | -0.1 |
| Waite Hoyt SP | 2 | 1 | 0 | 4.78 | 8 | 8 | 43.1 | 38 | 25 | 23 | 7 | 21 | 37 | 1.36 | .239 | .270 | 0.7 |
| Jamie Moyer SP | 8 | 6 | 0 | 5.01 | 47 | 15 | 133.0 | 140 | 80 | 74 | 23 | 42 | 88 | 1.37 | .275 | .290 | 1.5 |
| Mark Buehrle SP | 8 | 12 | 0 | 5.11 | 34 | 31 | 185.0 | 200 | 113 | 105 | 37 | 55 | 130 | 1.38 | .282 | .299 | 2.6 |
| Hoyt Wilhelm RP | 3 | 3 | 2 | 5.23 | 46 | 0 | 65.1 | 62 | 40 | 38 | 14 | 25 | 56 | 1.33 | .250 | .264 | 0.2 |
| David Price SP | 3 | 6 | 1 | 5.33 | 34 | 11 | 99.2 | 104 | 65 | 59 | 24 | 31 | 96 | 1.35 | .266 | .292 | 1.0 |
| Joe Horlen SP | 1 | 1 | 0 | 5.33 | 9 | 3 | 27.0 | 27 | 16 | 16 | 3 | 13 | 21 | 1.48 | .265 | .308 | 0.4 |
| Billy Loes SP | 1 | 1 | 1 | 5.45 | 33 | 0 | 34.2 | 43 | 23 | 21 | 12 | 14 | 36 | 1.64 | .303 | .326 | -0.4 |
| A. J. Minter RP | 5 | 4 | 17 | 5.54 | 54 | 0 | 50.1 | 47 | 31 | 31 | 7 | 22 | 26 | 1.37 | .246 | .253 | 0.3 |
| Joe Lake SP | 4 | 5 | 0 | 5.79 | 22 | 5 | 65.1 | 80 | 44 | 42 | 12 | 14 | 54 | 1.44 | .302 | .338 | 1.1 |
| Ben Sheets SP | 6 | 12 | 0 | 5.88 | 33 | 26 | 165.1 | 169 | 111 | 108 | 43 | 49 | 147 | 1.32 | .264 | .280 | 1.4 |
| Larry Twitchell LF | 3 | 2 | 0 | 6.06 | 18 | 1 | 35.2 | 47 | 25 | 24 | 6 | 7 | 30 | 1.51 | .322 | .369 | 0.6 |
| Sam Streeter SP | 0 | 3 | 0 | 6.62 | 9 | 5 | 35.1 | 32 | 27 | 26 | 9 | 17 | 39 | 1.39 | .254 | .295 | 0.3 |
| Tom Williams SP | 4 | 3 | 4 | 6.75 | 41 | 0 | 42.2 | 43 | 32 | 32 | 11 | 16 | 39 | 1.38 | .262 | .281 | -0.1 |
| Tricky Nichols RP | 5 | 8 | 0 | 7.27 | 25 | 20 | 107.2 | 137 | 91 | 87 | 31 | 45 | 67 | 1.69 | .316 | .315 | -0.4 |
| Scott Radinsky RP | 0 | 1 | 0 | 7.82 | 12 | 0 | 12.2 | 13 | 12 | 11 | 4 | 8 | 18 | 1.66 | .255 | .310 | -0.1 |
| Gavin Floyd SP | 2 | 1 | 0 | 8.05 | 10 | 1 | 19.0 | 24 | 17 | 17 | 7 | 3 | 16 | 1.42 | .324 | .327 | -0.1 |
| Fernando Rodney CL | 1 | 2 | 2 | 8.53 | 15 | 0 | 12.2 | 21 | 13 | 12 | 4 | 7 | 13 | 2.21 | .389 | .447 | -0.2 |
| Herb Pennock SP | 0 | 2 | 0 | 9.30 | 12 | 1 | 20.1 | 31 | 21 | 21 | 9 | 10 | 14 | 2.02 | .352 | .338 | -0.6 |
| Wilbur Wood RP | 0 | 2 | 0 | 14.04 | 8 | 0 | 8.1 | 20 | 13 | 13 | 5 | 2 | 6 | 2.64 | .455 | .455 | -0.4 |
