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| Name | W | L | SV | ERA | G | GS | IP | HA | R | ER | HR | BB | K | WHIP | OAVG | BABIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Akinori Otsuka RP | 3 | 1 | 1 | 2.93 | 21 | 0 | 27.2 | 22 | 10 | 9 | 3 | 12 | 27 | 1.23 | .214 | .260 | 0.6 |
| Ed Walsh SP | 5 | 2 | 1 | 3.11 | 15 | 13 | 92.2 | 59 | 34 | 32 | 16 | 39 | 90 | 1.06 | .184 | .200 | 1.7 |
| Jamie Moyer SP | 2 | 1 | 0 | 3.24 | 23 | 5 | 58.1 | 47 | 24 | 21 | 8 | 17 | 37 | 1.10 | .215 | .223 | 0.8 |
| Ted Lilly SP | 0 | 0 | 0 | 4.15 | 5 | 0 | 8.2 | 10 | 4 | 4 | 2 | 5 | 5 | 1.73 | .294 | .286 | -0.1 |
| Mark Buehrle SP | 5 | 7 | 0 | 4.61 | 16 | 16 | 99.2 | 93 | 52 | 51 | 20 | 29 | 65 | 1.22 | .252 | .256 | 1.1 |
| Ben Sheets SP | 4 | 7 | 0 | 4.75 | 15 | 15 | 91.0 | 85 | 51 | 48 | 16 | 26 | 80 | 1.22 | .249 | .280 | 1.7 |
| Cristóbal Torriente CF | 0 | 0 | 0 | 4.91 | 3 | 0 | 3.2 | 3 | 2 | 2 | 1 | 1 | 3 | 1.09 | .231 | .222 | -0.0 |
| Hoyt Wilhelm RP | 3 | 3 | 2 | 5.40 | 27 | 0 | 43.1 | 38 | 26 | 26 | 13 | 20 | 38 | 1.34 | .230 | .217 | -0.7 |
| David Price RP | 3 | 4 | 1 | 5.42 | 19 | 11 | 74.2 | 85 | 50 | 45 | 19 | 22 | 69 | 1.43 | .283 | .308 | 0.6 |
| A. J. Minter RP | 2 | 3 | 11 | 5.66 | 24 | 0 | 20.2 | 22 | 13 | 13 | 4 | 10 | 10 | 1.55 | .272 | .269 | -0.2 |
| Tricky Nichols SP | 4 | 6 | 0 | 5.99 | 16 | 16 | 82.2 | 100 | 58 | 55 | 18 | 32 | 49 | 1.60 | .305 | .314 | 0.3 |
| Larry Twitchell SP | 3 | 2 | 0 | 6.06 | 18 | 1 | 35.2 | 47 | 25 | 24 | 6 | 7 | 30 | 1.51 | .322 | .369 | 0.6 |
| Billy Loes RP | 0 | 1 | 1 | 6.27 | 19 | 0 | 18.2 | 26 | 14 | 13 | 8 | 9 | 14 | 1.87 | .313 | .295 | -0.7 |
| Tom Williams RP | 1 | 0 | 0 | 6.46 | 15 | 0 | 15.1 | 15 | 11 | 11 | 2 | 4 | 16 | 1.24 | .250 | .310 | 0.3 |
| Joe Lake SP | 2 | 2 | 0 | 6.52 | 9 | 0 | 19.1 | 25 | 14 | 14 | 3 | 3 | 17 | 1.45 | .301 | .349 | 0.3 |
