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| Name | W | L | SV | ERA | G | GS | IP | HA | R | ER | HR | BB | K | WHIP | OAVG | BABIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Akinori Otsuka RP | 4 | 1 | 3 | 2.09 | 29 | 0 | 38.2 | 24 | 10 | 9 | 3 | 16 | 35 | 1.03 | .178 | .216 | 1.0 |
| Ed Walsh SP | 7 | 6 | 1 | 3.61 | 22 | 20 | 134.2 | 96 | 58 | 54 | 27 | 54 | 128 | 1.11 | .200 | .212 | 2.1 |
| Ted Lilly SP | 0 | 0 | 0 | 4.15 | 5 | 0 | 8.2 | 10 | 4 | 4 | 2 | 5 | 5 | 1.73 | .294 | .286 | -0.1 |
| Joe Lake SP | 4 | 3 | 0 | 4.76 | 18 | 1 | 45.1 | 48 | 26 | 24 | 8 | 8 | 32 | 1.24 | .271 | .290 | 0.6 |
| David Price RP | 3 | 5 | 1 | 4.84 | 30 | 11 | 93.0 | 96 | 55 | 50 | 21 | 28 | 88 | 1.33 | .264 | .291 | 1.1 |
| Jamie Moyer SP | 2 | 5 | 0 | 4.92 | 29 | 11 | 86.0 | 91 | 52 | 47 | 17 | 32 | 51 | 1.43 | .272 | .276 | 0.4 |
| Mark Buehrle SP | 7 | 9 | 0 | 4.96 | 22 | 22 | 134.1 | 133 | 75 | 74 | 28 | 38 | 94 | 1.27 | .264 | .273 | 1.6 |
| Hoyt Wilhelm RP | 3 | 3 | 2 | 5.31 | 40 | 0 | 57.2 | 51 | 34 | 34 | 13 | 23 | 47 | 1.28 | .237 | .239 | -0.1 |
| Ben Sheets SP | 4 | 12 | 0 | 5.77 | 20 | 20 | 117.0 | 122 | 78 | 75 | 26 | 35 | 104 | 1.34 | .269 | .295 | 1.5 |
| Cristóbal Torriente CF | 0 | 0 | 0 | 5.79 | 4 | 0 | 4.2 | 4 | 3 | 3 | 1 | 1 | 4 | 1.07 | .235 | .250 | 0.0 |
| Tom Williams RP | 1 | 0 | 1 | 5.84 | 24 | 0 | 24.2 | 25 | 16 | 16 | 5 | 8 | 23 | 1.34 | .263 | .299 | 0.1 |
| Larry Twitchell SP | 3 | 2 | 0 | 6.06 | 18 | 1 | 35.2 | 47 | 25 | 24 | 6 | 7 | 30 | 1.51 | .322 | .369 | 0.6 |
| Billy Loes RP | 0 | 1 | 1 | 6.27 | 19 | 0 | 18.2 | 26 | 14 | 13 | 8 | 9 | 14 | 1.87 | .313 | .295 | -0.6 |
| A. J. Minter RP | 4 | 3 | 13 | 6.28 | 32 | 0 | 28.2 | 32 | 20 | 20 | 7 | 12 | 14 | 1.53 | .278 | .266 | -0.4 |
| Tricky Nichols RP | 5 | 8 | 0 | 7.27 | 24 | 20 | 107.2 | 137 | 91 | 87 | 31 | 45 | 67 | 1.69 | .316 | .315 | -0.5 |
