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| Name | W | L | SV | ERA | G | GS | IP | HA | R | ER | HR | BB | K | WHIP | OAVG | BABIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Andrew Miller SP | 8 | 8 | 6 | 4.21 | 74 | 0 | 77.0 | 58 | 42 | 36 | 12 | 41 | 84 | 1.29 | .212 | .256 | 1.2 |
| Skel Roach RP | 2 | 1 | 3 | 4.31 | 41 | 0 | 39.2 | 19 | 19 | 19 | 0 | 40 | 44 | 1.49 | .143 | .213 | 0.8 |
| Jameson Taillon SP | 4 | 5 | 0 | 4.71 | 29 | 11 | 91.2 | 82 | 51 | 48 | 17 | 30 | 64 | 1.22 | .243 | .252 | 1.2 |
| Stubby Overmire SP | 13 | 10 | 0 | 4.72 | 35 | 33 | 211.2 | 207 | 114 | 111 | 37 | 59 | 144 | 1.26 | .255 | .269 | 4.4 |
| Jonathan Papelbon CL | 3 | 5 | 19 | 4.83 | 43 | 0 | 41.0 | 37 | 23 | 22 | 6 | 17 | 38 | 1.32 | .242 | .282 | 1.0 |
| Dean Chance SP | 1 | 1 | 0 | 4.86 | 12 | 6 | 50.0 | 48 | 27 | 27 | 13 | 19 | 38 | 1.34 | .259 | .259 | 0.2 |
| Len Barker SP | 11 | 12 | 0 | 4.99 | 33 | 33 | 180.1 | 180 | 111 | 100 | 27 | 79 | 161 | 1.44 | .261 | .304 | 4.3 |
| Armando Benitez CL | 0 | 0 | 2 | 5.40 | 12 | 0 | 10.0 | 9 | 6 | 6 | 1 | 7 | 11 | 1.60 | .237 | .308 | 0.2 |
| Bucky Walters SP | 0 | 3 | 0 | 5.73 | 10 | 5 | 33.0 | 32 | 23 | 21 | 9 | 13 | 30 | 1.36 | .254 | .261 | 0.2 |
| Carl Mays SP | 1 | 0 | 0 | 6.00 | 1 | 1 | 6.0 | 5 | 4 | 4 | 2 | 3 | 4 | 1.33 | .217 | .176 | -0.0 |
| Tommy de la Cruz SP | 1 | 5 | 5 | 6.12 | 36 | 0 | 50.0 | 47 | 34 | 34 | 14 | 14 | 49 | 1.22 | .244 | .252 | 0.2 |
| Bill Doak RP | 5 | 4 | 0 | 6.37 | 27 | 11 | 89.0 | 99 | 68 | 63 | 27 | 42 | 88 | 1.58 | .284 | .305 | 0.0 |
| Sadie McMahon SP | 0 | 1 | 0 | 6.49 | 10 | 2 | 26.1 | 31 | 19 | 19 | 7 | 11 | 23 | 1.59 | .295 | .316 | 0.1 |
| Heath Bell CL | 3 | 5 | 2 | 6.53 | 58 | 0 | 71.2 | 75 | 56 | 52 | 18 | 35 | 74 | 1.53 | .270 | .303 | -0.1 |
| David Bush SP | 9 | 9 | 0 | 6.58 | 46 | 19 | 149.0 | 157 | 111 | 109 | 40 | 40 | 122 | 1.32 | .272 | .277 | 0.6 |
| Jon Lester SP | 7 | 9 | 0 | 6.61 | 35 | 25 | 147.0 | 148 | 111 | 108 | 36 | 83 | 149 | 1.57 | .265 | .294 | 1.1 |
| Eddie Cicotte SP | 2 | 2 | 0 | 6.70 | 21 | 3 | 47.0 | 54 | 35 | 35 | 12 | 24 | 38 | 1.66 | .290 | .302 | -0.0 |
| Shane Bieber SP | 0 | 3 | 0 | 7.36 | 9 | 8 | 33.0 | 36 | 27 | 27 | 8 | 11 | 26 | 1.42 | .279 | .289 | 0.4 |
| Bob Stanley RP | 1 | 1 | 0 | 8.78 | 12 | 0 | 13.1 | 19 | 13 | 13 | 5 | 2 | 10 | 1.57 | .328 | .318 | -0.1 |
| Nixey Callahan SP | 2 | 4 | 0 | 8.83 | 16 | 4 | 35.2 | 42 | 35 | 35 | 12 | 26 | 37 | 1.91 | .294 | .309 | -0.5 |
| Derek Lowe SP | 0 | 1 | 0 | 10.52 | 13 | 1 | 25.2 | 42 | 32 | 30 | 9 | 8 | 31 | 1.95 | .356 | .423 | -0.1 |
