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| Name | W | L | SV | ERA | G | GS | IP | HA | R | ER | HR | BB | K | WHIP | OAVG | BABIP | WAR |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Jonathan Papelbon CL | 2 | 2 | 11 | 2.45 | 24 | 0 | 22.0 | 17 | 7 | 6 | 3 | 11 | 23 | 1.27 | .212 | .259 | 0.6 |
| Skel Roach RP | 1 | 0 | 0 | 2.91 | 21 | 0 | 21.2 | 8 | 7 | 7 | 0 | 17 | 27 | 1.15 | .111 | .178 | 0.6 |
| Heath Bell CL | 1 | 2 | 2 | 4.46 | 25 | 0 | 34.1 | 36 | 21 | 17 | 6 | 11 | 41 | 1.37 | .271 | .345 | 0.6 |
| Andrew Miller SP | 5 | 4 | 1 | 4.54 | 32 | 0 | 35.2 | 24 | 20 | 18 | 6 | 20 | 38 | 1.23 | .195 | .228 | 0.4 |
| Stubby Overmire SP | 5 | 5 | 0 | 5.36 | 15 | 13 | 87.1 | 95 | 53 | 52 | 13 | 29 | 60 | 1.42 | .281 | .308 | 1.8 |
| Len Barker SP | 4 | 8 | 0 | 5.42 | 14 | 14 | 74.2 | 80 | 48 | 45 | 15 | 25 | 58 | 1.41 | .274 | .295 | 1.2 |
| Jameson Taillon SP | 1 | 2 | 0 | 5.51 | 17 | 2 | 32.2 | 29 | 21 | 20 | 7 | 13 | 23 | 1.29 | .242 | .244 | 0.1 |
| Jon Lester SP | 3 | 2 | 0 | 5.57 | 14 | 14 | 72.2 | 65 | 48 | 45 | 14 | 39 | 69 | 1.43 | .244 | .271 | 0.9 |
| David Bush SP | 4 | 1 | 0 | 5.73 | 28 | 2 | 59.2 | 62 | 39 | 38 | 16 | 16 | 49 | 1.31 | .267 | .274 | -0.2 |
| Carl Mays SP | 1 | 0 | 0 | 6.00 | 1 | 1 | 6.0 | 5 | 4 | 4 | 2 | 3 | 4 | 1.33 | .217 | .176 | -0.0 |
| Dean Chance SP | 0 | 0 | 0 | 6.14 | 4 | 0 | 7.1 | 11 | 5 | 5 | 3 | 1 | 9 | 1.64 | .355 | .421 | -0.1 |
| Bill Doak RP | 4 | 3 | 0 | 6.53 | 16 | 11 | 71.2 | 79 | 54 | 52 | 21 | 31 | 73 | 1.53 | .283 | .310 | 0.2 |
| Shane Bieber SP | 0 | 3 | 0 | 7.36 | 9 | 8 | 33.0 | 36 | 27 | 27 | 8 | 11 | 26 | 1.42 | .279 | .289 | 0.3 |
| Eddie Cicotte SP | 1 | 1 | 0 | 8.16 | 6 | 1 | 14.1 | 20 | 13 | 13 | 2 | 8 | 11 | 1.95 | .323 | .360 | 0.2 |
| Nixey Callahan SP | 1 | 1 | 0 | 13.00 | 5 | 1 | 9.0 | 11 | 13 | 13 | 4 | 13 | 10 | 2.67 | .306 | .304 | -0.5 |
| Derek Lowe RP | 0 | 1 | 0 | 13.25 | 10 | 1 | 18.1 | 33 | 29 | 27 | 8 | 7 | 22 | 2.18 | .379 | .439 | -0.3 |
